Working with GLP-1s — without prescribing them.

We don’t prescribe them. Plain statement.

Twin Cities Metabolism is not a GLP-1 clinic. Dr. Jared Larsen doesn’t prescribe semaglutide, tirzepatide, liraglutide, or any other GLP-1 receptor agonist. If a GLP-1 prescription is what you’re looking for, your primary care provider or an obesity medicine specialist is the right next step — not us.

Our work is functional medicine: measuring what’s actually driving metabolic dysfunction at the root and addressing it with diet, supplementation, exercise, sleep, stress, and gut and hormone interventions. We think that’s a different question than what GLP-1s answer. We treat the two as complementary, not competing.

Before a GLP-1

Addressing why your body might be heading there.

Some patients come to us asking the same question their doctor is starting to ask: do I need a GLP-1? Insulin resistance, stubborn weight, blunted satiety, food cravings that don’t quit, A1c climbing year over year — these can all be addressed without a GLP-1 if the metabolic roots are addressed early enough.

The Metabolic Blueprint quantifies the root drivers (insulin resistance, gut microbiome, hormone cascade, inflammation, thyroid signaling) and gives you a written plan to address them. If the foundation work moves the needle, you may never need a GLP-1. If it doesn’t move the needle far enough on its own, you’ll have a Metabolic Blueprint to share with whoever prescribes for you next.

Currently on a GLP-1

What we add to your treatment.

If you’re on Ozempic, Wegovy, Mounjaro, or any GLP-1 right now, we are familiar with the work and can support you alongside the medication. Specifically, we measure what your GLP-1 prescription doesn’t:

• Resting metabolic rate. GLP-1s suppress appetite, which can drop calorie intake fast — and your metabolism follows. We track whether yours is suppressing.
• Body composition. Trial data shows that roughly 25–40% of weight lost on GLP-1s is lean tissue — about 25% on tirzepatide and 39–40% on semaglutide (SURMOUNT-1 DXA substudy, Look et al., 2025; STEP-1 body composition substudy, Wilding et al., 2021). We measure lean mass directly via InBody scan and flag if you’re losing muscle, not just weight.
• Lab panels every 3 months. Lipids, fasting insulin, A1c, vitamin D, iron panel, thyroid — what your prescribing clinician may not be looking at.

Translation: we don’t prescribe the medication, and we don’t oppose it. We make sure your body comes through the treatment in better shape than it would otherwise.

Coming off a GLP-1

Rebuilding the foundation.

GLP-1 weight regain after stopping is real — published data shows most patients regain a substantial fraction of lost weight within 12 months of discontinuation. That doesn’t have to be the trajectory.

Patients who come to us transitioning off a GLP-1 typically get the Metabolic Blueprint first, then the Reset program. The Blueprint surfaces what’s actually driving the metabolic rebound (often gut microbiome shifts during the medication period, suppressed RMR, and lean-mass loss). The Reset is the 6-month structured rebuild: foundational nutrition, supplement protocol, exercise programming, biweekly visits, in-clinic measurement at each visit.

If you want to come off a GLP-1 and keep the gains, that’s the right sequence.